Korean J Physiol Pharmacol 2025; 29(1): 9-19
Published online January 1, 2025 https://doi.org/10.4196/kjpp.24.115
Copyright © Korean J Physiol Pharmacol.
Hye Young Mun1, Septika Prismasari1, Jeong Hee Hong2, Hana Lee3, Doyong Kim3, Han Sung Kim3, Dong Min Shin4, and Jung Yun Kang1,*
1Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, 2Department of Physiology, College of Medicine, Gachon University, Lee Gil Ya Cancer and Diabetes Institute, Incheon 21999, 3Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, 4Department of Oral Biology, Yonsei University College of Dentistry, Seoul 03722, Korea
Correspondence to:Jung Yun Kang
E-mail: hannahkang@yonsei.ac.kr
Author contributions: H.Y.M. and J.Y.K. conceptualized and designed the study and acquired, analyzed, and interpreted data. Experiments were performed by H.Y.M., S.P., H.L., D.K., and H.S.K. H.Y.M., S.P., and J.Y.K. drafted the manuscript and acquired data. J.H.H. and D.M.S revised the manuscript critically for important intellectual content. J.Y.K. contributed to the funding acquisition and final approval of the published version and are responsible for all aspects of the work as regards the accuracy and integrity of the study.
Fine particulate matter (FPM) is a major component of air pollution and has emerged as a significant global health concern owing to its adverse health effects. Previous studies have investigated the correlation between bone health and FPM through cohort or review studies. However, the effects of FPM exposure on bone health are poorly understood. This study aimed to investigate the effects of FPM on bone health and elucidate these effects in vitro and in vivo using mice. Micro-CT analysis in vivo revealed FPM exposure decreased bone mineral density, trabecular bone volume/total volume ratio, and trabecular number in the femurs of mice, while increasing trabecular separation. Histological analysis showed that the FPM-treated group had a reduced trabecular area and an increased number of osteoclasts in the bone tissue. Moreover, in vitro studies revealed that low concentrations of FPM significantly enhanced osteoclast differentiation. These findings further support the notion that short-term FPM exposure negatively impacts bone health, providing a foundation for further research on this topic.
Keywords: Air pollution, Bone and bones, Osteoclasts, Particulate matter, X-ray microtomography
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