Korean J Physiol Pharmacol 2022; 26(6): 541-556

Published online November 1, 2022 https://doi.org/10.4196/kjpp.2022.26.6.541

Copyright © Korean J Physiol Pharmacol.

Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

Junxiong Zhao^1,2,#, Qian Wu^3,#, Ting Yang^1,4,#, Liangui Nie², Shengquan Liu², Jia Zhou⁵, Jian Chen⁶, Zhentao Jiang⁷, Ting Xiao^8,*, Jun Yang^2,*, and Chun Chu^1,*

¹Department of Pharmacy, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421000, ²Department of Cardiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421000, ³Department of General Practice, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421000, ⁴School of Pharmaceutical Science of University of South China, Hengyang 421000, ⁵Department of Ultrasound Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421000, ⁶Department of Critical Care Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421000, ⁷Department of Cardiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421000, ⁸Department of Cardiology, Shenzhen Longhua District Central Hospital, Longhua Central Hospital Affiliated Guang-dong Medical University, Shenzhen 518000, China

Correspondence to:Chun Chu
E-mail: yjchuchun@163.com
Jun Yang
E-mail: yangjunketizu@163.com
Ting Xiao
E-mail: 1459593600@qq.com

Author contributions: J.Z. and Q.W. were responsible for the execution of the experiments and the writing of the manuscript. T.Y., L.N., S.L., and J.Z. participated in molecular biology testing and experimental design, J.C. and Z.J. were responsible for the execution of experiments and data analysis. T.X., J.Y., and C.C. were responsible for the design of the experiment. All authors contributed to this work and approved the submitted version.

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