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Review Article

Korean J Physiol Pharmacol 2022; 26(5): 297-305

Published online September 1, 2022

Copyright © Korean J Physiol Pharmacol.

Effects of sleep deprivation on coronary heart disease

Ran Wei1,2, #, Xiaoye Duan1, #, and Lixin Guo1,2,*

1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 2Peking University Fifth School of Clinical Medicine, Beijing, China

Correspondence to:Lixin Guo

#These authors contributed equally to this work.

Author contributions: R.W. consulted literatures and wrote the manuscript. L.G. designed the review. X.D. assisted with writing and revised the manuscript. All authors contributed to the article and approved the submitted version.

Received: November 18, 2021; Revised: March 6, 2022; Accepted: June 10, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. Sleep deprivation (SD) is a severe health problem in modern society. Meanwhile, as with cardiometabolic disease, there was an obvious tendency that coronary heart disease (CHD) to become a global epidemic chronic disease. Specifically, SD can significantly increase the morbidity and mortality of CHD. However, the underlying mechanisms responsible for the effects of SD on CHD are multilayered and complex. Inflammatory response, lipid metabolism, oxidative stress, and endothelial function all contribute to cardiovascular lesions. In this review, the effects of SD on CHD development are summarized, and SD-related pathogenesis of coronary artery lesions is discussed. In general, early assessment of SD played a vital role in preventing the harmful consequences of CHD.

Keywords: Coronary heart disease, Inflammatory response, Lipid metabolism, Oxidative stress, Sleep deprivation