Fig. 5. Multi-electrode array (MEA) analysis of electrophysiological responses to eight arrhythmogenic drugs in hiPSC-CMs (CMC-011).
MEA evaluation depicting the percentage alterations in field potential duration (FPD), corrected FPD (FPDc), beat period, and amplitude in response to varying concentrations of eight arrhythmogenic drugs: E4031, nifedipine, mexiletine, JNJ303, flecainide, moxifloxacin, quinidine, and ranolazine. The arrhythmic beats observed with mexiletine, JNJ303, moxifloxacin, and ranolazine are represented as the number of occurrences relative to the total number of repetitions (observations/repetitions). The blue dot line indicates the 20% change threshold for FPD and FPDc. The arrow indicates the FPD20 or FPDc20, with the depth of the red color representing the decrease in FPD20 or FPDc20. hiPSC-CMs, human induced pluripotent stem cell-derived cardiomyocytes.
© Korean J Physiol Pharmacol
