Fig. 4. Multi-electrode array (MEA) analysis of electrophysiological responses to eight arrhythmogenic drugs in hiPSC-CMs (CMC-006).
MEA analysis showing changes in field potential duration (FPD), corrected FPD (FPDc), beat period, and amplitude (expressed as percentages) in response to varying concentrations of eight drugs: E4031, nifedipine, mexiletine, JNJ303, flecainide, moxifloxacin, quinidine, and ranolazine. The arrhythmic beats observed with E4031 are represented as the number of occurrences relative to the total number of repetitions (observations/repetitions). The blue dot line indicates the 20% change threshold for FPD and FPDc, which is considered biologically relevant for cardiotoxicity. The arrow indicates the FPD20 or FPDc20, with the depth of the red color representing the decrease in FPD20 or FPDc20. hiPSC-CMs, human induced pluripotent stem cell-derived cardiomyocytes.
© Korean J Physiol Pharmacol
