Fig. 3. Maltol treatment enhances phospholamban (PLN) phosphorylation and modulates Ca2+ handling signaling proteins in mdx hearts.
(A) Representative immunoblots showing phosphorylation levels of PLN and PLN in WT and mdx mice hearts treated with vehicle or maltol. GAPDH was used as a loading control. (B) Quantitative analysis of phosphorylated PLN and total PLN in WT and mdx mice hearts. (C) Immunoblots showing expression levels of SERCA2a and NCX1 in WT and mdx mice hearts treated with vehicle or maltol. (D) Quantitative analysis of SERCA2a and NCX1 in WT and mdx mice hearts treated with vehicle or maltol. Data are means ± SD. WT, wild-type; VEH, vehicle; MAL, maltol; ns, not significant. *p < 0.05.
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