Fig. 2. Maltol treatment improves cardiac function in mdx mice with Duchenne muscular dystrophy.
(A) Experimental design and treatment regimen for mdx and WT mice with maltol. (B) Body weight (BW) changes in WT and mdx mice treated with vehicle or maltol. (C) Representative M-mode echocardiography images of WT and mdx mice. Quantitative analysis of (D) systolic left ventricular internal diameter (LVIDs), (E) fractional shortening (FS), (F) ejection fraction (EF), (G) left ventricular posterior wall thickness (LVPWd), (H) interventricular septal thickness (IVSd), (I) heart rate (HR) in WT and mdx mice treated with vehicle or maltol. Each dot represents an individual animal. Data are means ± SD. PO, per os; WT, wild-type; VEH, vehicle; MAL, maltol; ns, not significant. *p < 0.05.
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