Fig. 2. Summary of functional interplay between mouse caspase-11 non-canonical inflammasome and autophagy.
(A) Inhibitory role of autophagy in caspase-11 non-canonical inflammasome during infection with vacuolar gram-negative bacteria in mouse macrophages. (B) Inhibitory role of autophagy in NRF2-mediated caspase-11 non-canonical inflammasome activation and HMGB1 release during inflammatory responses in hepatocytes. (C) Inhibitory role of autophagy-related proteins in caspase-11 non-canonical inflammasome in macrophages and LPS-induced acute lethal septic mice. (D) Induction of autophagy by caspase-11 non-canonical inflammasome in response to bacterial infection in the macrophages. HMGB1, high‐mobility group box 1; LPS, lipopolysaccharide; GBP, guanylate‐binding protein.
© Korean J Physiol Pharmacol
