Fig. 3. Effects of LCB 03-0110, tacrolimus, or tofacitinib on the expression levels of IL-6 and IL-8 in HCE-2 cells.
HCE-2 cells were incubated with only KSFM, (A, B) 1 µg/ml LPS or (C, D) 25 µg/mL poly(I:C) in the presence of LCB 03-0110, tacrolimus, or tofacitinib (0.3, 1, 3, and 9 μM). The data are shown as a ratio compared with only the LPS- or poly(I:C)-treated group in the absence of compounds. **p < 0.01, *p < 0.05 compared with the only LPS- or poly(I:C)-induced group in the absence of compounds. The data are presented as the mean ± SD (n = 3). IL, interleukin; HCE-2, human corneal epithelial cells; KSFM, keratinocyte serum-free medium; LPS, lipopolysaccharide.
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