Fig. 3. PA9RA alleviates atherosclerotic lesion in ApoE–/– mouse.
Atherosclerotic plaques in the heart aortic root were stained with Oil-red O (ORO) and plaque area was measured. (A) Quantitative analysis of atherosclerotic lesion area (percent of ORO positive area in the total staining area). Data is presented as mean ± SEM (n = 6). *p ≤ 0.05 vs. negative control group. (B) Representative image of sections of heart aortic root from negative control, clopidogrel, atorvastatin, PA9RA 5 mg/kg/day, 15 mg/kg/day, and 45 mg/kg/day treated groups. The atherosclerotic lesion area is decreased in PA9RA 45 mg/kg/day treated group. Scale bar: 100 µm. PA9RA, potassium retinoate.
© Korean J Physiol Pharmacol
