Fig. 2. PA9RA alleviates liver lesion in ApoE–/– mouse.
Centrilobular microvesicular steatosis and lobular inflammation in the liver were analyzed for liver injury using H&E. (A) Semi-quantitative analysis of liver injury. Data is presented as mean ± SEM (n = 6). **p ≤ 0.001 vs. negative control group. (B) Representative image of the liver from negative control, clopidogrel, atorvastatin, PA9RA 5 mg/kg/day, 15 mg/kg/day, and 45 mg/kg/day treated groups. Centrilobular steatosis is decreased in PA9RA 45 mg/kg/day treated group. Scale bar: 200 µm. PA9RA, potassium retinoate.
© Korean J Physiol Pharmacol
