Fig. 5. Tasquinimod promoted the anti-tumor of cisplatin in OC/DDP cells xenografts in mice.
(A–C) Tumor volume and weight were measured and compared in mice after treatment with Tasquinimod combined with cisplatin. (D) Immunofluorescence analysis of HDAC4 expression levels in tumor cells in mice. (E) Western blot analysis of HDAC4, p21, cyclin D1, and CDK4 expression levels in mouse tumor tissues. (F) Flow cytometry analysis of apoptosis in tumor tissues in mice. All experiments were independently repeated three times. Tukey’s test and one-way ANOVA were used to analyze statistical significance. Values are presented as mean ± SD. OC, ovarian cancer; HDAC4, histone deacetylase 4; IOD, integrated optical density. *p < 0.05 vs. SKOV3 or A2780 group, #p < 0.05 vs. SKOV3/DDP or A2780/DDP group.
© Korean J Physiol Pharmacol
