Fig. 3. Tasquinimod affected the cell cycle of cisplatin-resistant OC/DDP cells.
(A) Flow cytometry analysis of the cell cycle in SKOV3/DDP and A2780/DDP cells after Tasquinimod treatment. (B, C) qRT-PCR and Western blot analyses of p21 expression levels in SKOV3/DDP and A2780/DDP cells after Tasquinimod treatment. All experiments were independently repeated three times. Tukey’s test and one-way ANOVA were used to analyze statistical significance. Values are presented as mean ± SD. OC, ovarian cancer; HDAC4, histone deacetylase 4; NC, negative control. *p < 0.05 vs. SKOV3/DDP + NC or A2780/DDP + NC group, #p < 0.05 vs. SKOV3/DDP or A2780/DDP group.
© Korean J Physiol Pharmacol
