Fig. 1. Tasquinimod enhanced the anti-proliferative and pro-apoptotic effects of cisplatin in OC/DDP cells.
(A) Western blot analysis verified that Tasquinimod inhibited HDAC4 expression in SKOV3/DDP and A2780/DDP cells. (B) CCK8 assays were used to assess the effects of Tasquinimod monotherapy on the viability of SKOV3/DDP and A2780/DDP cells. (C) Flow cytometry was used to detect apoptosis in SKOV3/DDP and A2780/DDP cells treated with Tasquinimod monotherapy. All experiments were independently repeated three times. Tukey’s test and one-way ANOVA were used to analyze statistical significance. Values are presented as mean ± SD. OC, ovarian cancer; HDAC4, histone deacetylase 4; CCK8, cell counting kit-8. *p < 0.05 vs. SKOV3 or A2780 group, #p < 0.05 vs. SKOV3/DDP or A2780/DDP group, &p < 0.05 vs. SKOV3/DDP cells or A2780/DDP cells group, $p < 0.05 vs. SKOV3/DDP cells + cisplatin or A2780/DDP cells + cisplatin group.
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