Fig. 1. Expression profiling of store-operated calcium entry (SOCE)-associated genes in renal cell carcinoma (RCC) subtypes.
(A, C) Heatmaps depict the expression patterns of five SOCE-related genes and all samples in clear cell RCC (ccRCC) and papillary RCC (pRCC), respectively. Cells represent the z-transformed (across samples) expression value of each gene. (B, D) Violin plots represent the differential patterns of the five genes between cancer and normal. Dotted lines, points, and whiskers represent the median value, interquartile range (IQR), and extreme values (maximum and minimum) no further than 1.5 × IQR. (E) The z-scores of log RNA-seq V2 RSEM were calculated based on all normal samples of ccRCC and pRCC expressing relative mean mRNA expression values for Orai1-3 and STIM1, 2. The z-score threshold ± 3. Box whisker plots express the minimum, median, and maximum values. (F) Relative frequency of genetic alterations of Orais and STIMs in ccRCC (“C”) and pRCC (“P”) using cBioPortal web. Alteration types, mRNA low (or Shallow deletion) and high (or Gain), were analyzed by copy number alteration (CNA) using GISTIC (Genomic Identification of Significant Targets In Cancer). Data were compared using Student’s t-test (B, D, and E). ns., not significant. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.
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