Fig. 3. Micro-CT analysis to investigate the effects of fine particulate matter (FPM) on the femoral cortical bone in mice.
(A) Representative micro-CT transverse cross-sectional images of the cortical bone from each group. Mean changes in cortical parameters over time were measured (control group, n = 5, FPM-treated group, n = 7, and LPS-treated group, n = 3). (B, C) Mean percentage changes in cortical bone parameters in the treatment groups based on the pre-treatment value at Day 0. Treatment commenced in 6-week-old mice and was stopped after 19 days. Significant differences between each group normalized to the baseline values before application are noted (p < 0.05, Kruskal–Wallis test): (B) Bone mineral density (BMD), (C) cross-sectional thickness (Cs.Th), (D) cortical bone volume (Ct.BV), and (E) mean polar moment of inertia (MMI). The control group received PBS (10 ml/kg), FPM-treated group received PBS-diluted FPM (7.5 mg/kg), and LPS-treated group received lipopolysaccharide (5 mg/kg). Bars represent mean ± standard deviation. LPS, lipopolysaccharide; CT, computed tomography; PBS, phosphate-buffered saline.
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