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Fig. 7. Effect of hemin on the AMPK/SIRT1/PGC-1 α/HO-1/NF-κB signaling pathway in the lung tissue of mice with pulmonary fibrosis (PF). (A) Western blotting detection of the expression of proteins related to the AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathway in the lung tissue of mice with PF. (B) p-AMPK/AMPK ratio. (C) SIRT1/GAPDH ratio. (D) PGC-1α/GAPDH ratio. (E) HO-1/GAPDH ratio. (F) p-NF-κB p65/NF-κB p65 ratio. The significance of difference was determined by one-way ANOVA followed by Tukey’s test. The data are presented as the means ± standard deviations. Three mice were in each group. AMPK, adenosine monophosphate-activated protein kinase; SIRT1, silent information regulator 1; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator-1α; HO-1, heme oxygenase-1; NF-κB, nuclear transcription factor-κB. **p < 0.01 compared with the control group. #p < 0.05 and ##p < 0.01 compared with the bleomycin group.
Korean J Physiol Pharmacol 2024;28:559-568 https://doi.org/10.4196/kjpp.2024.28.6.559
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