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Fig. 7. Schematic illustration. The protective effect of 6’-sialyllactose in LPS-induced macrophage inflammation via regulating Nrf2-mediated oxidative stress and inflammatory signaling pathways. LPS, lipopolysaccharide; TLR4, Toll-like receptor 4; Akt, protein kinase B; ROS, reactive oxygen species; NF-κB, nuclear factor kappa-light chain enhancer of activated B cells; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; MMP9, matrix metalloproteinase-9; Nrf2, nuclear factor erythoid 2-related factor 2; Keap1, kelch-like ECH-associated protein 1; ARE, antioxidant response element; HO-1, heme oxygenase-1.
Korean J Physiol Pharmacol 2024;28:503-513 https://doi.org/10.4196/kjpp.2024.28.6.503
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