Fig. 3. BK channel activation downregulates ET-1 and mitigates vascular endothelial dysfunction in CIH-treated rats.
(A) Detection of ET-1 levels in rat serum. (B) Western blotting analysis of ET-1 protein expression in rat aortic tissues. (C) Vascular tone assessment. N = 6. The data were presented as mean ± standard deviation. Data between two groups was compared using the unpaired student’s t-test, and data comparison among multiple groups was conducted with a one-way analysis of variance, with Tukey’s for post-hoc test. ET-1, endothelin-1; CIH, chronic intermittent hypoxia; DMSO, dimethyl sulfoxide, PE, phenylephrine; ACh, acetylcholine; SNP, sodium nitroprusside. *p < 0.05 compared to the DMSO group.
© Korean J Physiol Pharmacol
