Fig. 1. Vascular dysfunction occurs, and BK channel activity is repressed in chronic intermittent hypoxia (CIH)-treated rats.
(A) Systolic blood pressure (SBP) in the normoxia and CIH groups. (B) Diastolic blood pressure (DBP). (C) Mean blood pressure (MBP). (D) Vascular tone assessment. (E) H&E staining to detect pathological changes in rat aorta. (F) Immunohistochemistry to measure the expression of BK channels in rat aortic tissues. N = 6. The data were expressed as mean ± standard deviation. Data comparison between two groups was performed with the unpaired student’s t-test, and data comparison among multiple groups was conducted with a one-way analysis of variance, with Tukey’s for post-hoc test. IOD, integrated optical density; PE, phenylephrine; ACh, acetylcholine; SNP, sodium nitroprusside. *p < 0.05 compared with the normoxia group.
© Korean J Physiol Pharmacol
