Fig. 6. The effects of the TRPC channel inhibitors such as flufenamic acid and SKF96365 on low [Mg²⁺]_o-induced epileptiform activity. (A) Flufenamic acid (100 μM) significantly inhibited the spike firing of low [Mg²⁺]_o-induced epileptiform activity, but SKF96365 (10 μM) did not affect inhibited the spike firing of the epileptiform activity. (B) Graph summarizes the spike firing and amplitude of low [Mg²⁺]_o-induced epileptiform activity in non (control, n = 7)-, flufenamic acid (n = 7)- and SKF96365 (n = 7)-treated groups. Data are expressed as means ± SEM. TRPC, transient receptor potential canonical; [Mg²⁺]_o, extracellular Mg²⁺ concentration. *p < 0.05 relative to respective control (one way ANOVA with Bonferroni’s test).

Korean J Physiol Pharmacol 2024;28:413-422 https://doi.org/10.4196/kjpp.2024.28.5.413

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