Fig. 5. The protein kinase C inhibitors GF109203X and chelerythrine increase the spike firing of low [Mg²⁺]_o-induced epileptiform activity. (A) GF109203X (1 μM) and chelerythrine (10 μM) significantly increased the spike firing of low [Mg²⁺]_o-induced interictal epileptiform activity. (B) Graph summarizes the spike firing and amplitude of the interictal epileptiform activity in non (control, n = 8)-, GF109203X (n = 7)- and chelerythrine (n = 5)-treated groups. Data are expressed as means ± SEM. [Mg²⁺]_o, extracellular Mg²⁺ concentration. *p < 0.05 relative to control, **p < 0.01 relative to control (one way ANOVA with Bonferroni’s test).

Korean J Physiol Pharmacol 2024;28:413-422 https://doi.org/10.4196/kjpp.2024.28.5.413

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