Fig. 3. The phospholipase C inhibitor U73122 inhibits the spike firing of low [Mg²⁺]_o-induced epileptiform activity. (A) Exposure to Mg²⁺-free ACSF induced epileptiform activity in the CA1 region. U73122 (10 μM) significantly inhibited the spike firing of low [Mg²⁺]_o-induced epileptiform activity. (B) Graph summarizes the spike firing and amplitude of low [Mg²⁺]_o-induced epileptiform activity in non (control, n = 6)- and U73122 (n = 7)-treated groups. Data are expressed as means ± SEM. [Mg²⁺]_o, extracellular Mg²⁺ concentration; ACSF, artificial cerebrospinal fluid. **p < 0.01 relative to respective control (non-paired Student’s t-test).

Korean J Physiol Pharmacol 2024;28:413-422 https://doi.org/10.4196/kjpp.2024.28.5.413

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