Fig. 2. DHPG enhances the spike firing of low [Mg²⁺]_o-induced epileptiform activity in the CA1 region of rat hippocampal slice. (A) Exposure to low [Mg²⁺]_o induced epileptiform activity in the CA1 region of rat hippocampal slices. The group 1 mGluR agonist DHPG (10 µM) increased the spike firing of the epileptiform activity. (B) Graph summarizes the spike firing and amplitude of the low [Mg²⁺]_o-induced epileptiform activity in non (control, n = 7)-, DHPG (n = 6)-treated groups in the CA1 region. Data are expressed as means ± SEM. DHPG, 3,5-dihydroxyphenylglycine; [Mg²⁺]_o, extracellular Mg²⁺ concentration; mGluR, metabotropic glutamate receptor. **p < 0.01 relative to respective control (non-paired Student’s t-test).

Korean J Physiol Pharmacol 2024;28:413-422 https://doi.org/10.4196/kjpp.2024.28.5.413

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