Fig. 1. The pathogenesis of flavivirus infections.
Mosquitoes, the main transmitters of flavivirus, initiate the infection by injecting the virus into humans (left panel). Generally, infection with flavivirus causes mild symptoms such as fever and leads to various physiological changes within the body (middle panel). When symptoms become severe, the infection can affect multiple organs (right panel). ZIKV infection can cause ocular diseases and neurological inflammation, and it can also lead to infection of the placenta. DENV infection can cause damage to endothelial cells, leading to plasma leakage. YFV infection can cause damage to hepatocytes. DENV, YFV and WNV infections can cause acute kidney injury or renal failure.
© Korean J Physiol Pharmacol
