Fig. 3. Liquiritigenin reduces HSP90-mediated CMA.
(A) STRING enrichment analysis showed that HSP90 is a key gene in CMA. RT-qPCR (B, D) and Western blotting (C, E) to detect the expression of CMA-related HSC70 and LAMP-2A in BC cells. The data are expressed as mean ± standard deviation. Each cell experiment was repeated thrice. HSP90, heat shock protein 90; CMA, chaperone-mediated autophagy; RT-qPCR, reverse transcription quantitative polymerase chain reaction; LAMP-2A, lysosome-associated membrane protein type 2A; BC, breast cancer. *p < 0.05, compared to 0 mmol/L group.
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