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Fig. 4. TR reduces PAI-1 expression induced by DEXA and increases tPA expression. Effect of TR on the (A) PAI-1 gene (B) PAI-1 protein (C) tPA gene and (D) tPA protein expressions by the DEXA-treated HTMCs after treatment for three and seven days. Bars represent mean ± SD (n = 3). *p < 0.05, ANOVA with Tukey’s post-hoc. TR, resveratrol; PAI-1, plasminogen activator inhibitor-1; DEXA, dexamethasone; tPA, tissue plasminogen activator; HTMC, human trabecular meshwork cell; DMEM, Dulbecco’s modified Eagle medium; DMSO, dimethyl sulfoxide.
Korean J Physiol Pharmacol 2024;28:345-359
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