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Fig. 3. TR alleviates TGF- β1 and SMAD expressions induced by DEXA but increases inhibitory SMAD 7. Effect of TR on the (A) TGF-β1 gene (B) Total TGF-β1 protein (C) Active TGF-β1 protein (D) SMAD4 gene (E) SMAD4 protein (F) SMAD7 gene (G) SMAD7 protein by the DEXA-treated HTMCs after treatment for three and seven days. Bars represent mean ± SD (n = 3). *p < 0.05, ANOVA with Tukey’s post-hoc. TR, resveratrol; DEXA, dexamethasone; HTMC, human trabecular meshwork cell; DMEM, Dulbecco’s modified Eagle medium; DMSO, dimethyl sulfoxide.
Korean J Physiol Pharmacol 2024;28:345-359
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