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Fig. 2. Alterations of global Ca2+ signaling in the presence of diphenyleneiodonium (DPI). (A) Ca2+ transients measured in a representative ventricle cell followed by caffeine (10 mM)-induced Ca2+ signals in the absence and presence of 3 μM DPI. (B, C) Summary of mean values of the diastolic and systolic Ca2+ levels, and in the magnitude, time-to-90%-peak (TP,90) and half decay time of Ca2+ transient in the absence (Con) and presence of DPI (3 μM) (n = 15). ****p < 0.0001, **p < 0.01 vs. Con (Paired t-test). (D) Comparison of magnitudes of the caffeine-induced Ca2+ transients and fractional release measured before (Control) and after application of DPI (3 μM) (n = 15). ****p < 0.0001 vs. Con (Paired t-test).
Korean J Physiol Pharmacol 2024;28:335-344
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