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Fig. 1. Negative inotropy induced by diphenyleneiodonium (DPI) in rat ventricular myocytes. (A) Representative contraction traces recorded immediately before (“Control”) and after the exposure to different concentrations of DPI in field-stimulated rat ventricular myocytes at 1 Hz. The traces were selected when a maximal decrease in cell shortening by DPI was observed. (B) Concentration-dependent decrease in cell shortenings (% suppression) by the extracellular application of DPI; 0.01 μM, n = 3, p > 0.05; 0.05 μM, n = 4, p < 0.01; 0.1 μM, n = 4, p < 0.01; 1 μM, n = 6, p < 0.001; 10 μM, n = 6, p < 0.0001; 10 μM, n = 4, p < 0.001. Paired t-test was used. The sigmoidal curve represents the fit of the Hill equation.
Korean J Physiol Pharmacol 2024;28:335-344 https://doi.org/10.4196/kjpp.2024.28.4.335
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