Fig. 9. Potentiating effects of 3,3′,4,4′-tetrachlorobiphenyl (PCB77) on Kv1.3 current are irreversible.
Currents were evoked by a 200 ms depolarizing pulse to +60 mV from a holding potential of −60 mV at 10 s intervals before exposure to PCB77 (baseline), during the application of 10 nM PCB77, and washout. Steady-state currents were normalized to the baseline values. Normalized currents during PCB77 washout were compared with currents evoked in untreated oocytes after the same recording duration (n = 3 oocytes per treatment).
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