Fig. 7. 3,3′,4,4′-tetrachlorobiphenyl (PCB77) shifts the steady-state Kv1.3 current activation curve to more depolarized potentials.
(A, B) Representative steady-state activation tail currents recorded at −50 mV after 100 ms of depolarizing pulses from −70 to +60 mV in the absence and presence of 3 and 10 nM PCB77. (C) Steady-state activation curves were obtained by normalizing each tail current to the traces evoked at +60 mV and by fitting the data to the Boltzmann equation. Data are presented as the mean ± SEM (n = 5–7 oocytes per treatment).
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