Fig. 6. Slowing of Kv1.3 current kinetics by 3,3′,4,4′-tetrachlorobiphenyl (PCB77).
The time constants of current activation and inactivation were estimated by fitting each exponential function to traces evoked by a single +50 mV pulse for a 2-s duration from a holding potential of −60 mV. (A) Representative normalized current traces of the activation phase in the absence of PCB77 (dark) and the presence of 3 and 10 nM PCB77 for 15 min (colored). Each current trace was normalized to its peak value. (B) Representative normalized current traces for the inactivation phase in the absence of PCB77 and in the presence of 3 and 10 nM PCB77 for 15 min. (C, D) Summary of the activation time constants (C) and inactivation time constants (D). Data are presented as the mean ± SEM (n = 6–11 oocytes per concentration, *p < 0.05).
© Korean J Physiol Pharmacol
