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Fig. 5. Time and voltage-dependence of steady-state Kv1.3 current modulation by 3,3′,4,4′-tetrachlorobiphenyl (PCB77). (A) Current traces elicited by 2-s depolarizations of −20, +10, and +50 mV from a holding potential of −60 mV before (control) and after exposure to 3 and 10 nM PCB77. (B–E) PCB19-induced changes in peak and steady-state Kv1.3 currents at different command potentials. For each depolarizing voltage step, the current in the presence of 3 (B, C) or 10 nM PCB77 (D, E) at 8 and 15 min were normalized to the currents obtained in the absence of PCB77. Asterisks indicate significant differences between the peak and steady-state currents at each command potential in the presence of PCB77 vs. controls. Daggers indicate significant differences compared with the response at −30 mV. Data presented as mean ± SEM (n = 4–7 oocytes per concentration, *, p < 0.05).
Korean J Physiol Pharmacol 2024;28:323-333
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