Fig. 23,3′,4,4′-tetrachlorobiphenyl (PCB77) does not influence human Kv1.5 channel currents.
(A) Currents were evoked in oocytes using the same voltage pulse protocol as in
. (B) Current traces from a control oocyte and one treated with 10 nM PCB77 for 8 and 15 min. (C−F) Steady-state current–voltage (C, D) and peak current–voltage (E, F) relationships for human Kv1.5 currents in the presence of 0 (control), 3, and 10 nM PCB77 for 8 min (C, E) or 15 min (D, F). Steady-state currents were measured at the end of each 2-s depolarizing pulse shown as dotted lines. Peak and steady-state current magnitudes were normalized to the corresponding values at +50 mV. Data are presented as the mean ± SEM (n = 5–11 oocytes per concentration group).
