Fig. 2. 3,3′,4,4′-tetrachlorobiphenyl (PCB77) enhanced human steady-state Kv1.3 currents expressed in Xenopus oocytes.
(A) Currents were evoked by 2-s voltage pulses from a holding potential of −60 to +50 mV with an increment of 10 mV. (B) The current traces from a control oocyte and one treated with 10 nM PCB77 for 8 and 15 min. (C−F) Steady-state current–voltage (C, D) and peak current–voltage (E, F) relationships for human Kv1.3 currents in the presence of 0 (control), 3, and 10 nM PCB77 for 8 min (C, E) or 15 min (D, F). Steady-state currents were measured at the end of the 2-s pulse shown as dotted lines. Peak currents and steady-state currents were normalized to the corresponding values at +50 mV. Data are presented as the mean ± SEM (n = 4–11 oocytes per concentration group).
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