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Fig. 6. Whole-cell current recordings of p.A385T and p.R504T. Na+ channels were expressed by transfection in HEK293 cells in the presence of β1-subunit. (A) I-V relation of WT + β, p.A385T + β, and p.R504T + β. (B) Comparison of peak INa density. Compared to the WT group, p.R504T + β significantly reduced current density (p = 0.0167). *p < 0.05; **p < 0.01; ***p < 0.001. (C) Voltage dependence of activation and inactivation, and window current. (D) Time course of recovery from inactivation of WT, p.A385T, and p.R504T with β1-subunit. WT, wild type; N.S, not significant.
Korean J Physiol Pharmacol 2024;28:313-322 https://doi.org/10.4196/kjpp.2024.28.4.313
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