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Fig. 5. Characterization of Na+ channel property in the steady-state activation and inactivation in co-expressed β1-subunit. (A) Representative traces of voltage dependence of inactivation in the presence of β1-subunit. (B) Voltage dependence of activation and inactivation, and window current. (C) Representative traces of time course of recovery from inactivation of WT and p.A385T/R504T with β1-subunit. (D) The P2/P1 ratio was plotted against the inter-pulse interval, and the resulting curves were fitted with double-exponential functions. The time constants for the fast (p = 0.0250) and slow components were estimated from these plotted functions. p-value less than 0.05 was considered to be statistically significant, *p < 0.05. WT, wild type; N.S, not significant.
Korean J Physiol Pharmacol 2024;28:313-322
© Korean J Physiol Pharmacol