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Fig. 4. Reduced p.A385T/R504T INa co-transfected with β1-subunit. (A) Representative whole-cell Na+ current traces of WT and p.A385T/R504T in the presence of β1. (B) I-V relation of WT + β and p.A485T/R504T + β. (C) Comparison of peak INa density (p = 0.0027). p-value less than 0.05 was considered to be statistically significant, *p < 0.05; **p < 0.01. (D) Voltage dependence of activation for WT and p.A385T/R504T in the presence of β1-subunit measured form 12-20 cells. (E) Representative Western blotting image of NaV1.5 in transfected HEK293 cells with and without β1-subunit. WT, wild type; I-V, current-voltage; DB, double mutant; GFP, green fluorescent protein.
Korean J Physiol Pharmacol 2024;28:313-322
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