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Fig. 2. p.A385T/R504T does not affect Na+ current (INa) density. (A) Schematic drawing of the cardiac voltage-gated Na+ channel α-subunit (NaV1.5) showing position of the A385T/R504T in the loop connecting transmembrane segments 5 and 6 in domain 1 (S5-S6 in DI) and segments 6 and 1 between domain 1 and 2 (DI-DII linker). (B) Representative whole-cell Na+ current recordings of WT and p.A385T/R504T. (C) Average Na+ current-voltage (I-V) relation for WT and p.A385T/R504T channels. (D) Voltage-dependence of activation for WT and p.A385T/R504T channels by normalizing peak conductance against the membrane voltage. WT, wild type.
Korean J Physiol Pharmacol 2024;28:313-322
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