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Fig. 3. Effect of Vinp on the infiltration of immune cells. The effect of Vinp on immune cell infiltration and the numbers of (A) CD45+ and (C) F4/80+ cells in the DNCB-induced AD model were analyzed using IHC staining (left hand side: CD45+: magnification 100×, F4/80+: magnification 200×; scale bar: 100 µm). (B) CD45+ and (D) F4/80+ cells were examined for immune cell and macrophage infiltration and counted using ImageJ software. Data represent means ± SD (n = 5 or 6). Data were considered significant at ###p < 0.001 compared with the control group and **p < 0.01 and ***p < 0.001 compared with the DNCB group. IHC, immunohistochemistry; DNCB, 1-chloro-2,4-dinitrobenzene; Vinp, vinpocetine; Dex, dexamethasone; AD, atopic dermatitis.
Korean J Physiol Pharmacol 2024;28:303-312
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