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Fig. 2. Effect of Vinp on the thickness of dorsal skin tissue. (A) H&E staining was performed to investigate the changes in epidermal and dermal hyperplasia. To evaluate the effect of Vinp on DNCB-induced skin lesions, DNCB was repeatedly applied to the dorsal skin of Balb/c mice (left hand side: magnification 100×; scale bar: 100 µm). (B) DNCB application increased epidermal thickness by 3.39-fold compared with the control group. (C) DNCB application increased dermal thickness by 1.81-fold compared with the control group. However, Vinp treatment significantly inhibited DNCB-induced increases in epidermal and dermal thickness. Data represent means ± SD (n = 5 or 6). Data were considered significant at ###p < 0.001 compared with the control group and *p < 0.1, **p < 0.01, ***p < 0.001 compared with the DNCB group. DNCB, 1-chloro-2,4-dinitrobenzene; Vinp, vinpocetine; Dex, dexamethasone.
Korean J Physiol Pharmacol 2024;28:303-312
© Korean J Physiol Pharmacol