Fig. 1. The synthetic route and mass spectrometry results of AM2.
(A) Free metformin obtained from metformin hydrochloride is esterified with artesunate. Reagents and conditions: (a) DCM, NaOH, rt, 2 h; (b) DCM, EDCI, DMAP, rt, 12 h; (B) Mass detection result of AM2.
© Korean J Physiol Pharmacol
