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Fig. 3. Effect of SO2 on myocardial fibrosis in hyperthyroid rats. (A) Masson staining results of myocardial tissues in the control, L-Thy, L-Thy + SO2, and L-Thy + SO2 + HDX groups under 10 × 40x field of view (blue-stained part referred to the collagen fibers, and black arrows marked the collagen fibers), n = 3. Scale bar = 50 um. (B) Masson staining results of collagen volume fraction, *,#, and & meant p < 0.05 vs. the values in the control, L-Thy, and L-Thy + SO2 groups, respectively. (C–H) Western-Blot results of changes in expressions of Collagen I, Collagen III, MMP2, MMP3, and TIMP2 in myocardial tissues of rats in each group, n = 3. *, #, and & meant p < 0.05 vs. the values in the control, L-Thy, and L-Thy + SO2 groups, respectively. L-Thy, levothyroxine; SO2, sulfur dioxide; HDX, hydrogen deuterium exchange.
Korean J Physiol Pharmacol 2024;28:129-143 https://doi.org/10.4196/kjpp.2024.28.2.129
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