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Fig. 1. The role of 27OHChol in metabolic syndrome. Dysfunction in cholesterol metabolism leads to increased accumulation of 27OHChol in tissues. The accumulated 27OHChol induces metabolic stress and low-grade inflammation by activating monocytic lineage cells. Unless 27OHChol is removed from affected tissues, the inflammatory response becomes chronic. The tissue-specific chronic inflammation induced by 27OHChol leads to metabolic syndrome. 27OHChol, 27-hydroxycholesterol.
Korean J Physiol Pharmacol 2024;28:107-112
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