Fig. 4. Dose-dependent effect of naringenin on GABA-mediated slow and fast responses of substantia gelatinosa (SG) neurons.
(A, B) Representative traces showing dose-dependent effect of naringenin (1 μM, 10 μM, 100 μM, and 1 mM) on 30 μM GABA-induced slow and fast inward current, respectively. (C) A histogram compares the increasing tendency in the mean relative amplitude of 30 μM GABA-mediated slow responses in the presence of various concentrations of naringenin (n = 4). (D) A histogram compares the decreasing tendency in the mean relative amplitude of 30 μM GABA-mediated fast responses in the presence of various concentrations of naringenin (n = 5) (*p < 0.05, **p < 0.01, one-way ANOVA post-hoc Scheffe test).
© Korean J Physiol Pharmacol
