Fig. 2. Effects of naringenin and GABA-mediated responses of substantia gelatinosa (SG) neurons under a voltage clamp mode.
(A) A representative trace showing the effect of naringenin in a dose-dependent manner (1 μM, 10 μM, 100 μM, 1 mM, and 2 mM, n = 10). (B) A histogram illustrates a weak inward current observed above 1 mM concentration of naringenin. (C, D) A representative trace and histogram show no discernible effect of 0.5 mM naringenin on membrane current (n = 3). (E–H) Representative traces and histograms showing no desensitization of slow (E, G, n = 15) and fast (F, H, n = 6) GABA responses upon repeated application to SG neurons. (I) A histogram demonstrates no significant differences in the response mediated by GABA upon repeated application (total n = 21, paired t-test, p > 0.05, ns: not significant).
© Korean J Physiol Pharmacol
