Fig. 2. Lithium and exercise attenuated pancreatic α-cell mass without changing β-cell mass and blood insulin levels.
(A) Final blood insulin levels of type 1 diabetic mice after 12 weeks of lithium and/or exercise administration. (B, C) Representative images of pancreatic islets with insulin- and glucagon-positive cells labeled via immunofluorescence (B) and a quantified potion of glucagon-positive (GCG+) areas in the islets (C) (Scale bars = 100 µm). The detailed experiment procedures are in the method section. Data are presented as means ± S.E.M. NC, saline-received normal glycemic group; PC, streptozotocin (STZ)-induced hyperglycemic group; Li, lithium(Li)-administration to STZ-received mice; Ex, moderate exercise training to STZ-received mice; Li + Ex, co-administration of Li and exercise to STZ-received mice. *p < 0.05, ***p < 0.001.
© Korean J Physiol Pharmacol
