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Fig. 7. Calcium-mediated RGC responses to burst stimulation in the RD retina.
(A) Representative 1-second raw traces of RGCs in the RD retina without and with thapsigargin (Th) or Hi-Di solution. (B) Spontaneous firing rates of RGCs for RD, RD + Th, and RD + Hi-Di. Statistical differences in the graphs are indicated by asterisks (***p < 0.001). (C) Typical responses of RD RGCs to burst stimulation are shown as raster plots. Electrically-evoked RGC spikes are highlighted. The time window of the raster plot is set to ± 0.1 sec, with 0 sec representing the stimulus onset (red dashed line). In each raster plot (10 trials), the pulse number increases from top to bottom (#1–#5). The pulse amplitude and pulse duration are fixed with 30 μA and 100 μs/phase. Only RGCs 200 μm closest to the stimulation electrode are analyzed. (D) Normalized RGC response curves to burst stimulation. Error bars represent the standard error of the mean (SEM). Statistical differences in the response curves are indicated by asterisks (*p < 0.05, **p < 0.01, ***p < 0.001). RGC, retinal ganglion cell; RD, retinal degenerate; Hi-Di, high-divalent.
Korean J Physiol Pharmacol 2023;27:541-553
© Korean J Physiol Pharmacol