Fig. 2EThe concentration-response relationships for mecheliolide, costunolide and dehydrocostus lactone on recombinant TMEM16A-mediated CaCC currents in CHO cells.
(A) The time course of the effects of mecheliolide (1, 3, 10, 30, 100 μM) on TMEM16A currents tested at +80 mV. (B) Representative TMEM16A-mediated CaCC current traces (recorded using the voltage protocol indicated in ) before and after the effects of different concentrations of mecheliolide were stabilized. (C) The concentration-response relationships of mecheliolide, costunolide and dehydrocostus lactone on TMEM16A-mediated CaCC currents measured at +80 mV. Data were fitted by a logistic function. (D) IC₅₀ and E_max values of mecheliolide, costunolide and dehydrocostus lactone. n = 5 cells, per group. CaCC, Ca²⁺-activated Cl^– channel; CHO, Chinese hamster ovary.

Korean J Physiol Pharmacol 2023;27:521-531 https://doi.org/10.4196/kjpp.2023.27.6.521

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